A Study of Xanthurenic Acid Excretion by Swine1

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Abstract
A study is reported of the urinary xanthurenic acid excretion of pregnant and non-pregnant gilts and sows, and of growing pigs. No evidence was found of a derangement of trypto-phan or pyridoxine metabolism associated with pregnancy, such as that reported for some human subjects. Administration of DL-tryptophan resulted in an elevation of xanthurenic acid excretion which was unaffected by simultaneous administration of pyridoxine. Insulin had no effect on the excretion of xanthurenic acid, indicating that the substantial amounts of this compound found in the urine are not associated with the poor glucose tolerance which is alleged to be characteristic of the species.