Enantioselective Ruthenium-Catalyzed Ring-Closing Metathesis
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- 8 September 2001
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (20) , 3225-3228
- https://doi.org/10.1021/ol0165692
Abstract
The first enantioselective ruthenium olefin metathesis catalysts have been prepared, and high enantiomeric excesses (up to 90%) are observed in the desymmetrization of achiral trienes. A model consistent with the stereochemical outcome of the reactions is described and suggests side-on olefin binding and reorganization of the halide ligands.Keywords
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