Stimulation of Neutrophil Locomotion by Inosiplex

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Abstract
Experiments were performed to investigate the in vitro effects of inosiplex on the locomotion an oxidative metabolism of human neutrophilis. The drug, when used at the concentration of 500 &um;g/ml, significantly increased neutrophil random migration and chemotaxis. Enhancement of chemotaxis was due to an increased rate of locomotion as well as to an increased true chemotactic response. Inosiplex appeared to exert its effect on the whole migrating cell population. No significant effect on the oxidative metabolism of both resting and phagocytizing neutrophilis was found. The results suggest that the effect of inosiplex may be related chiefly to its effect on neutrophil locomotion.