Free Calcium Ion Concentration in Pregnancy: A longitudinal study on 22 normal pregnant women

Abstract
302 samples from 22 normal pregnancies were frozen and kept for the analysis of free calcium ion concentration [Ca2+ 7.4 at 37°c and pH 7.40, after equilibration with CO2. Individual regressions were performed, and the concentration was found to increase slightly but significantly (5%, p<0.005) with the progress of the pregnancy. This increase excludes hypocalcemia as the cause of parathyroid overactivity during pregnancy, and a higher set point of the parathyrin (PTH) secretion is suggested.

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