Ankylosing Spondylitis in a Large Kindred: Clinical and Genetic Studies
- 1 March 1975
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 5 (3) , 205-212
- https://doi.org/10.1111/j.1399-0039.1975.tb01215.x
Abstract
In a kindred of 66 members spanning four generations, seven cases of ankylosing spondylitis (AS) HAVE BEEN FOUND. Four of these were in a single sibship of 13. AS was associated with HL-A27 in three of the four involved siblings, but close linkage was shown to be unlikely. Knowledge of HL-A genotype has made possible informed counseling for younger members of the sibship of 13, some of whom, as teenagers, already have back pain.Keywords
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