Association of Cytomegalovirus (CMV) Infection with Cervical Cancer: Isolation of CMV from Cell Cultures Derived from Cervical Biopsy

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Abstract
CMV was isolated from cell cultures derived from 2 of 10 cervical cancer biopsies from patients in an advanced stage of the disease. Five serial passages were necessary before extensive cytopathic changes characteristic of CMV infection appeared. All patients tested had complement-fixing antibodies to both isolates in higher titers than to the prototype AD 169 strain. Six of 8 patients tested also had herpesvirus type 2 antibodies.