INTERACTION OF SOMATOMEDIN-C WITH AN ANTIBODY DIRECTED AGAINST THE SYNTHETIC C-PEPTIDE REGION OF INSULIN-LIKE GROWTH FACTOR-I
- 1 February 1980
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 50 (2) , 405-407
- https://doi.org/10.1210/jcem-50-2-405
Abstract
Insulin-like growth factor-I is a human plasma peptide with strong structural homology to human prosinsulin. This peptide has been classified as a somatomedin on the basis of its biological actions and growth hormone dependence. We have generated an antibody to the synthetic 12 amino acid C-peptide region of insulin-like growth factor-I and used it to compare three somatomedin preparations to insulin-like growth factor-I. We also compared these somatomedin preparations to insulin-like growth factor-I using the standard SM-C RIA. We conclude that insulin-like growth factor-I and somatomedin-C behave identically in these two RIA1s and are very similar if not identical molecules.Keywords
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