Studies on the Use of Dioxyline Phosphate in the Treatment of Angina Pectoris

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Abstract
Dioxyline phosphate, on the basis of pharmacologic studies, appeared to be worthy of trial in the treatment of the anginal syndrome. The patients were studied during a control period and during alternate periods of placebo and dioxyline phosphate administration. Exercise tolerance tests were performed during each of the three periods of observation. The dosage of dioxyline phosphate was 800 mg. per day orally. Five of the 12 patients with angina experienced fewer pains while taking dioxyline phosphate than they did during either the control period or the period of placebo administration. The low incidence of serious side reactions was a conspicuous feature of the study.