Decoding ARE-mediated decay: is microRNA part of the equation?
Open Access
- 14 April 2008
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 181 (2) , 189-194
- https://doi.org/10.1083/jcb.200712054
Abstract
Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay.Keywords
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