REGULATORY MECHANISMS IN CELL-MEDIATED IMMUNE RESPONSE V. DISTINCT LYT SUBSETS MEDIATE ANTIGEN-SPECIFIC AND ANTIGEN-NONSPECIFIC SUPPRESSION

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Abstract
Studies were undertaken to assess mouse T cell subpopulations mediating antigen-specific and antigen-nonspecific suppression of cytotoxic T lymphocyte (CTL) responses to alloantigens. It was 1st demonstrated that generation of the CTL response itself requires Lyt-1+2+ T cells. Subsequent studies then characterized 2 distinct suppressor pathways that regulate the CTL response. Antigen nonspecific suppression was mediated by Lyt-1+2-Ts [suppressor T] cells that were generated during in vitro culture from an Lyt-1+2- precursor population. In a 2nd pathway, antigen-specific suppression was mediated predominantly by Lyt-1-2+ Ts cells that were activated during the in vitro allosensitization of Lyt-1+2+ precursors. The in vitro CTL response to alloantigens is modulated by 2 different pathways of T-cell-mediated suppression, and these pathways are mediated by distinct Lyt-defined T cell subpopulations.

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