Interaction of aldoses with α-amino-acids or peptides

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Abstract
Contrary to the interpretation of Shiga [1938] the alkali additions necessary to keep the pH of a mixture soln. of glucose and glycine at its initial value do not express directly the amt. of reaction product. The % combination was calculated from the total alkali added at any moment during the reaction and the pH of the system. The reaction velocity decreased with increasing pH. The total of alkali additions for various pH values, when equilibrium was reached, showed a maximum. Glycine required a maximum of alkali additions near pH 9, while glycyl-glycine showed the maximum at pH 7.5-8. This fact was explained by the differences in the acidic dissociation constants of glycine and glycylglycjne and by the different equilibrium constant of their interaction with glucose. Shiga''s view that the reactions of glycine and glycylglycine with glucose are of different types is therefore erroneous.

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