Kaposi's sarcoma in immunosuppression possibly the result of a dual viral infection
- 1 February 1990
- Vol. 65 (3) , 492-498
- https://doi.org/10.1002/1097-0142(19900201)65:3<492::aid-cncr2820650320>3.0.co;2-c
Abstract
Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two types of virus-like particles. CMV DNA was identifiable in the cell line whereas infectious CMV could be isolated only after repeated passages (only after 3 months of culture). The other virus could not be identified, but did not appear to be either HIV or papilloma virus. The patient's tumor regressed after the discontinuation of cyclosporine therapy and the recovery from the acute CMV infection.This publication has 16 references indexed in Scilit:
- The Natural History of Kaposi's Sarcoma in the Acquired Immunodeficiency SyndromeAnnals of Internal Medicine, 1985
- Effect of dimethyl sulfoxide on interaction of human cytomegalovirus with host cell: Conversion of a nonproductive state of cell to a productive state for virus replicationVirology, 1985
- Cells Infected with Human Cytomegalovirus Release a Factor(s) that Stimulates Cell DNA SynthesisJournal of General Virology, 1984
- Oral manifestations of tumor and opportunistic infections in the acquired immunodeficiency syndrome (AIDS): Findings in 53 homosexual men with Kaposi's sarcomaOral Surgery, Oral Medicine, Oral Pathology, 1983
- Association of Herpesvirus Infections with T-Lymphocyte-Subset Alterations, Glomerulopathy, and Opportunistic Infections after Renal TransplantationNew England Journal of Medicine, 1983
- CYTOMEGALOVIRUS AND KAPOSI'S SARCOMA IN YOUNG HOMOSEXUAL MENThe Lancet, 1982
- Disseminated Kaposi's sarcoma syndrome in young homosexual menJournal of the American Academy of Dermatology, 1981
- Kaposi's sarcoma in recipients of renal transplantsThe American Journal of Medicine, 1979
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977
- Antibody patterns to herpesviruses in kaposi's sarcoma: Serological association of european kaposi's sarcoma with cytomegalovirusInternational Journal of Cancer, 1975