IL-3 facilitates lymphocyte hexose transport by enhancing the intrinsic activity of the transport system

Publisher Website
Google Scholar
Abstract
Interleukin 3 (IL-3) promotes the survival and proliferation of hematopoletlc cells of various lineages In culture. Like most other hematopoletlc colony stimulating factors, its mode of action Is unknown. However, binding of the lymphoklneinduces protein tyroslne phosphorylation and enhanced glucose transport In some myelold progenitor cells. We have studiedthe hexose uptake following IL-3 stimulation In IL-3-dependent pro-B cells. IL-3 facilitated the uptake of 2-deoxyglucosewithin 15 min. Kinetic analysis of the 2-deoxyglucose uptake attributed the enhanced transport to improved transporter function, while other hormones or cytokines affect glucose transport primarily via the number of cell surface transporters.

This publication has 0 references indexed in Scilit: