The Antibacterial Action of Penicillin Against Gram Negative Organisms
- 1 December 1944
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 100 (2605) , 500-501
- https://doi.org/10.1126/science.100.2605.500
Abstract
117 crude liquors and 86 partially purified penicillin solns. with a potency between 35 and 49,000 Oxf. units per ml., were prepd. from Penicillium notatum or P. chrysogenum. The crude liquors were mildly bacteriostatic in low dilutions against Eberthella typhosa, whereas the partially purified fractions were effective in dilutions from 1:400 to 1:32,000. The crystalline Na salt of penicillin was 64 times more potent against Staphylococcus aureus than against E. typhosa. Penicillin exerted an antibacterial action against a variety of Gram neg. organisms, except for Escherichia coli and Pseudomonas pyocyaneus. The antibacterial action against E. typhosa was destroyed by clarase, which contains penicillinase, and by exposure to 100[degree] C for 11/2 hrs. All expts. were done in vitro.This publication has 3 references indexed in Scilit:
- PenicillinJournal of Bacteriology, 1944
- Proceedings of Local Branches of the Society of American BacteriologistsJournal of Bacteriology, 1943
- Activity of Penicillin in vitroExperimental Biology and Medicine, 1942