LOCATION AND SEQUENCE OF ATHEROSCLEROTIC PLAQUE-FORMATION IN WHITE CARNEAU AND SHOW RACER PIGEONS - RE-EVALUATION AND REDEFINITION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 102  (11) , 581-586
Abstract
Sudan staining of gross specimens with correlated histologic sections was used to localize the accumulation of fat in the aortas of genetically susceptible and resistant strains of pigeons. The birds were maintained on a cholesterol-free grain diet, and studies were done sequentially from ages 1 mo.-4 yr. Evidence suggests that the accumulation of lipids in musculoelastic cushions located at the origin of small branches is not necessarily a precursor of complicated lesions, but that it occurs concurrently in susceptible and resistant strains. In the lesion area, lipid accumulation is more striking and occurs earlier in the susceptible strain. It precedes proliferation by 3-6 mo. In this model, 2 distinct types of fatty streaks can be identified and their biologic features can be defined and related to their propensity for atherogenesis.

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