Clinical effect of low-dose erythromycin chemotherapy on chronic sinusitis.

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Abstract
Fifty three patients with chronic sinusitis were treated with 600mg of erythromycin (EM) per day for an average of 5.5 month.Symptoms disappeared in 25 patients (52.1%), and some subjective improvement was noted in 21 cases (43.8%). Local signs of infection in the nasal cavity were significantly improved in 25 patients (52.1%). Improvement was observed during the second month in most cases. No positive correlation was noted between the efficacy of EM and the sensitivity to EM of microorganisms in the discharge from the middle nasal meatus. The clinical effects were less in patients with higher serum IgA before EM chemotherapy. The EM effect on chronic sinusitis was not considered to be associated with bactericidal control.Low-dose, long-term EM therapy is useful in the treatment of chronic sinusitis.

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