INTRAOCULAR IGE ANTIBODY INDUCED IN GUINEA-PIGS WITH ASCARIS-SUUM LARVAE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (10) , 976-981
Abstract
The systemic and local (intraocular) Ig[immunoglobulin]E antibody responses to infective and heat-killed A. suum larvae were examined in guinea pigs. IgE antibody, demonstrated by the 6-day P-K ]Praunitz-Kustner] test, was found in anterior chamber fluid following primary intravitreal injection of live 2nd-stage A. suum larvae and in some instances occurred when no serum P-K activity was demonstrable. No intraocular IgE antibody was induced by primary intravitreal injection of heat-killed larvae. A brisk intraocular and systemic IgE antibody response followed the secondary intravitreal injection of live or heat-killed larvae into animals systemically infected with A. suum. The guinea pig system promises to be a useful model for studying the immunopathology of human ocular parasite infections.

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