The hyperaemic response to a transient reduction in cerebral perfusion pressure
- 1 September 1992
- journal article
- Published by Springer Nature in Acta Neurochirurgica
- Vol. 115 (3-4) , 90-97
- https://doi.org/10.1007/bf01406364
Abstract
A mathematical model of cerebral blood flow and the cerebrospinal fluid circulation is described which permits the study of phenomena caused by dynamic changes in cerebrovascular autoregulatory or cerebrospinal fluid compensatory reserves. A transient decrease in cerebral perfusion pressure was produced by carotid artery compression. Comparison of the computer simulations with clinical and experimental data, reported elsewhere, suggests that the transient hyperaemic response (THR) is proportional to the strength of the autoregulatory response. The relationships between the magnitude and time course of the THR, and the period and level of reduction in CPP were studied. This model suggests that simple clinical tests based on the examination of THR using transcranial Doppler velocity measurements are of potential value for the non-invasive assessment of the autoregulatory reserve.Keywords
This publication has 16 references indexed in Scilit:
- Spasm index in subarachnoid haemorrhage: consequences of vasospasm upon cerebral blood flow and oxygen extractionActa Neurologica Scandinavica, 2009
- The Dynamics of Cerebral Blood Flow, Perfusion Pressure and CSF Circulation — A Modelling StudyPublished by Springer Nature ,1993
- Quantitative Comparison of Measurements of Cerebral Glucose Metabolic Rate Made with Two Positron CamerasJournal of Cerebral Blood Flow & Metabolism, 1991
- Simultaneous transcranial Doppler sonography and cerebral blood flow measurements of cerebrovascular CO2-reactivity in patients with aneurysmal subarachnoid haemorrhageBritish Journal Of Neurosurgery, 1991
- Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid hemorrhage in the rabbitJournal of Neurosurgery, 1990
- Transcranial Doppler Ultrasonography of the Middle Cerebral Artery in the Hemodynamic Assessment of Internal Carotid Artery StenosisArchives of Neurology, 1990
- Cerebral Arteriovenous MalformationsPublished by Springer Nature ,1986
- Use of Cerebral Blood Flow Measurements in the Prediction of Delayed Cerebral Ischemia Following Subarachnoid HemorrhagePublished by Springer Nature ,1985
- Cerebrospinal fluid pulse waveform as an indicator of cerebral autoregulationJournal of Neurosurgery, 1982
- Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flowJournal of Neurosurgery, 1980