Evaluation of Drug Therapy and Teratogenic Risk in a Rhone-Alpes District Population of Pregnant Epileptic Women

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Abstract
The authors describe a sample of 148 pregnancies in identified epileptic women from 2 distinct sources: questionnaires sent a group of women, 15-45 years old, having had an EEG between 1976 and 1983, and a computerized registry involving all pregnancies occurring in 3 maternity wards in Lyon between 1979 and 1983. The analysis of drug therapy during early pregnancy showed that the most common regimen was monotherapy. Either in mono- or in polytherapies, phenobarbitone was the drug used most often, the second being valproic acid (67 and 25% of monotherapies, respectively). The epileptic mothers were younger than the controls, and had had fewer pregnancies. Sex and birthweight distribution did not differ from those of the controls. Twenty-six malformed infants (17.7%) were registered. Among them, 18 (70%) had minor defects only. No major malformation was observed in the ''no drug'' group, 6.7 and 7.7% of major malformations were observed in the monotherapy and polytherapy groups, respectively.

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