Surfactant Solutions as Media for Dissolution Testing of A Poorly Water-Soluble Drug

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Abstract
The solubility of a poorly water soluble drug. 4-(4-biphenylyl)-butanol (I) was dramatically enhanced in the presence of anionic, cationic and non-ionic surfactants. Since I has no bioavailability problems on oral dosing of capsules, physiological surfactants may be involved in the solubilization of I in vivo. Thus, surfactant solutions were selected as the most relevant media for dissolution testing of capsules of I. The intrinsic dissolution of I was examined in water, sodium dodecyl sulfate (SDS), and polyoxyethylene lauryl ether (POE lauryl ether) solutions, and increases were observed. Capsule dissolution in SDS solutions was not very successful: possible reasons are discussed. POE lauryl ether was selected as the surfactant of choice. The intrinsic dissolution rates were not a linear function of concentration of POE lauryl ether in the medium. Reasons for these observations are discussed. Dissolution of capsules was examined in various concentrations of the surfactant and an optimum concentration selected.