DISTRIBUTION OF PROLIFERATING DONOR CELLS IN RUNT DISEASE IN RATS

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Abstract
Proliferation of injected B.N.-strain lymphoid cells in neonatal Lewis rats suffering from runt disease has been investigated by means of sex chromosome differences. Throughout the course of the disease (4–21 days) dividing donor cells were present in large numbers in the lymph nodes of recipient rats, were much less common in the spleen, and rare in the thymus and bone marrow. The severity of the disease was roughly correlated with the frequency of dividing donor cells. Donor cell proliferation was a significant factor in lymph node enlargement, but splenomegaly largely resulted from proliferation of host cells. The interaction of host and donor lymphoid populations appears fundamental in the pathogenesis of runt disease, but the exact mechanism of death remains unknown.

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