Repair during fractionated irradiation of the mouse bladder

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Abstract
The capacity for repair of sublethal damage during fractionated irradiation of the mouse bladder was measured. Graded doses of electrons were given as 1, 2 or 5 equal daily fractions. Two functional end points were used to assess bladder damage: increased urination frequency and decreased bladder capacity. Repair of sublethal injury within 24 h was similar using both assays for bladder damage and was greater than the repair observed in mouse skin for a given dose per fraction. The possibility of a slower repair process occurring in bladder was investigated by giving 2 fractions in increasing overall times (from 24 h to 1 mo.). No increased repair was observed with the longer time intervals; hence there was no evidence for slow repair in the bladder.

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