Drug combination treatment in patients with ALS

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Abstract
Motor neuron survival in chick embryonic tissue culture is only 4.8% in the control medium, whereas the percentage of the survival increases to 14.5% when insulin-like growth factor-I (IGF-I) is added, 51.9% with basic fibroblast growth factor (bFGF), and 60.7% with ciliary neurotrophic factor (CNTF). [1] When these trophic molecules are combined in the culture media, the percentage of motor neuron survival rises to 76.1% with a combination of bFGF and IGF-I, 87% with CNTF and IGF-I, and 98.2% with bFGF and CNTF. A combination of all three trophic factors (bFGF, IGF-I, and CNTF), however, does not increase the survival further. Concerning the survival of in vitro motor neurons, a combination of bFGF and CNTF appears to be most effective. [1] Although these studies demonstrate a partially additive effect of the combination, [1] similar studies have shown that a combination of CNTF and bFGF results in survival-promoting effects that are more than …

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