3D Model of Human Arylamine N-Acetyltransferase 2: Structural Basis of the Slow Acetylator Phenotype of the R64Q Variant and Analysis of the Active-Site Loop
- 1 February 2002
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 291 (1) , 116-123
- https://doi.org/10.1006/bbrc.2002.6414
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- Arylamine N-acetyltransferases – of mice, men and microorganismsTrends in Pharmacological Sciences, 2001
- An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes.Human Molecular Genetics, 2000
- Structure of arylamine N-acetyltransferase reveals a catalytic triadNature Structural & Molecular Biology, 2000
- Update on consensus arylamine N-acetyltransferase gene nomenclaturePharmacogenetics, 2000
- Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2Biochemical Journal, 2000
- Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesisBiochemical Journal, 1997
- Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumoursCytogenetic and Genome Research, 1997
- Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populationsPharmacogenetics, 1996
- Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2. Functional analysis of recombinant NAT1/NAT2 chimeras expressed in Escherichia coli.Journal of Biological Chemistry, 1994
- SHORT COMMUNICATION: Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-AmericansCarcinogenesis: Integrative Cancer Research, 1993