The One-Point Method as Clinical Tool to Calculate and/or Adjust Dosage Regimen

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Abstract
The one-point method is presented as clinical tool to calculate the dosage regimen for patients where differences in steady state blood levels are expected due to change in volume of distribution (edema, obesity, myocardial or coronary infarction, hypoalbuminemia, displacement from protein binding, etc). The one-point method is based on the cmin'. - and superposition methods using a single blood sample upon administration of a test dose during the first dosing interval. This method is indicated when assessment of the dosage regimen is complicated by a change in either the volume of distribution, Vd, or the elimination rate constant, k,el or when the distribution coefficient. δ, is not known. There are various clinical situations in which Vd, is altered, such as in patients with edema, obesity, recent coronary or myocardial infarction, hepatic failure, hypoalbuminemia, displacement from protein binding due to other concomitantly given drugs, etc.