The role of alpha and beta adrenergic receptors in constriction and dilation of the systemic capacitance vessels: A study with measurements of the mean circulatory pressure in dogs.

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Abstract
The response of the mean circulatory pressure (MCP), an index of the tone of the systemic capacitance vessels, to the infusion of an .alpha.-adrenergic receptor stimulant (phenylephrine) and a .beta.-adrenergic receptor stimulant (isoproterenol) was studied in anesthetized, open-chest dogs. Provided that the blood volume (particularly, extra volume) remains constant, an increase in the MCP indicates an increase in the tone of the capacitance vessels (venoconstriction) and a decrease in the MCP indicates a decrease in the tone of the capacitance vessels (venodilation). The stimulation of the .alpha.-adrenergic receptor led to the increased tone of the systemic capacitance vessels and the stimulation of the .beta.-adrenergic receptor did not decrease the tone of the systemic capacitance vessels in anesthetized, open-chest dogs, but the stimulation of the .beta.-adrenergic receptor decreased the tone of the systemic capacitance vessels, when the tone had been previously elevated by angiotensin-II.

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