Storage of Carmine in Mice of Inbred Strains
- 1 March 1948
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 67 (3) , 315-317
- https://doi.org/10.3181/00379727-67-16288
Abstract
Intra-peritoneal injns. of aqueous lithium carmine solns. were given to 33 C3H mice and to 26 C57B mice. They were sacrificed 24 or 48 hrs. later, and the dye storage was examined in micro-sections. Particular attention was given to the liver, by using a rough estimation of carmine-storing Kupffer cells. By this method an inferior ability to store carmine was observed in C3H animals, as compared with the findings in the C57B strain. The storage in the spleen showed a similar, though less marked, difference between the 2 strains. Earlier unpublished expts. indicated that also Marsh-albino mice possess a lower dye-storing ability than C57B animals. The possible relationship between reticuloendothelial storage and the spontaneous tumor incidence in inbred mouse strains is discussed.Keywords
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