Abstract
In urinary calculus disease there remains a group of patients with no demonstrable biochemical abnormality. A method is described measuring particulate activity in freshly voided urine using a Coulter Counter, which demonstrates the abnormality in these cases. Urine from 100 normal controls and 100 persons with urinary calculus disease was analysed, demonstrating a statistically significant difference between the 2 groups (P less than 0.001).

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