Synthèse de cétones encombrées via réduction de nitriles tertiaires en présence de métaux alcalins

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Abstract
The reaction of alkali metals with tertiary alkyl nitriles eventually gives, after protonation, an imine. α-tert-Alkylketones are produced by the hydrolysis of these imines. This reaction, involving radical anion intermediates, is a simple method for the synthesis of highly hindered symmetric ketones.

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