Irradiation and Anticoagulant Therapy to Prevent Pulmonary Metastases of the V2 Carcinoma in Rabbits

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Abstract
Irradiated cancer cells disappeared from the circulating blood more quickly than nonirradiated cancer cells. Single doses of heparin or fibrinolysin reduced the production of pulmonary metastases by both irradiated and nonirradiated cells. The decrease was greatest with the irradiated cells. Heparin and fibrinolysin administered daily for six days after the i ntravenous inoculation of irradiated cancer cells markedly reduced the occurrence of pulmonary metastases.