Effects of Leukotrienes C4, D4, and E4 on Cerebral Arteries of Newborn Pigs

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Abstract
We examined effects of topical application of leukotrienes (LT) C4, D4, and E4 on cerebral arteries of newborn pigs in vivo. Diameters of pial arteries were measured using a cranial window method during application of artificial cerebrospinal fluid without drug, and cerebrospinal fluid containing LT C4, D4, and E4 (1, 10, 100, 1000, and 5000 ng/ml). Control diameters ranged from 51–345 μm. All three LT constricted pial arteries in a dose-dependent manner, with a threshold for detectable response at 10 ng/ml (7 ± 3% for LTD4). The magnitude of constrictor response at the highest dose was 23 ± 3% for LTC4, 17 ± 2% for LTD4, and 17 ± 3% for LTE4. The specific receptor antagonist FPL 55712 blocked the constrictor response to LT. We conclude that LT are potent constrictors of cerebral arteries in newborn pigs.