Studies in Creatinine and Uric Acid Metabolism

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Abstract
Daily output of creatinine undergoes marked variations and is not so constant as supposed. Daily variations in creatinine and uric acid excretions, on creatine-creatinine and purine-free diet, follow one another closely. This correlation points to analogous origin,[long dash]uric acid from hypoxanthin of muscle (Burian and Schur) and creatinine from creatine of muscle. Ingestion of uric acid in man causes increase in creatinine output, probably due to transformation of iminazole nucleus in uric acid to creatinine. Ingestion of nuclein-rich material (thymus and pancreas) causes increase in uric acid output but does not affect creafinine. The difference is probably due to appearance of uric acid in blood in more insoluble and less easily excretable form in the 1st case, hence transformation to creatinine (and urea); and in easily excretable form in 2nd case, hence no need for transformation. Uric acid given to dogs per os causes large increase in allantoin output, but no effect on creatinine. Presence of the enzyme uricase in dogs probably accounts for this. In man the ratio of uric acid to creatinine is about 1:4. In dogs the ratio of allantoin to creatinine is about 2.4:1. Ratios similar to the latter were found in cat, rat, guinea pig, rabbit.

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