mmr , a Mycobacterium tuberculosis Gene Conferring Resistance to Small Cationic Dyes and Inhibitors
- 15 November 1998
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 180 (22) , 6068-6071
- https://doi.org/10.1128/jb.180.22.6068-6071.1998
Abstract
The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.Keywords
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