CHANGES IN HEART WEIGHT AND BLOOD PRESSURE FOLLOWING AORTIC CONSTRICTION IN RATS

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Abstract
Blood pressure measurements in the carotid and femoral arteries of rats after subdiaphragmatic aortic constriction, taken at times varying from immediately afterwards to 5 days after, indicate that increased carotid pressure precedes cardiac enlargement in these animals. The large drop in femoral blood pressure within the first few hours after aortic constriction seems to be due[long dash]at least partly[long dash]to stimulation of the pressoreceptors by the increased aortic-carotid pressure. Hypertrophy of the left ventricle can be shown on the second day after constriction. Maximum height of carotid pressure obtainable after epinephrine injection rises with the time after constriction, while the rise over the preinjection value does not increase.