Sialyltransferases in cancer
- 1 January 2001
- journal article
- review article
- Published by Springer Nature in Glycoconjugate Journal
- Vol. 18 (11/12) , 841-850
- https://doi.org/10.1023/a:1022288022969
Abstract
It has long been known that cancer cells often express more heavily sialylated glycans on their surface and that this feature sometimes correlates with invasion. It is now well established that specific sialylated structures, such as the Thomsen-Friedenreich-related antigens, the sialyl Lewis antigens, the sialyl α2-6 lactosaminyl structure, the polysialic acid or some gangliosides, can mediate cellular interactions and are altered in cancer cells. This review summarizes the current knowledge on the cancer-associated alterations in sialyltransferase expression which are often at the basis of the deranged expression of sialylated structures.Keywords
This publication has 97 references indexed in Scilit:
- Quantitative lectinhistochemical and immunohistochemical studies on the occurrence of alpha(2,3)- and alpha(2,6)-linked sialic acid residues in colorectal carcinomas. Relation to clinicopathologic featuresCancer, 1995
- Human Colon Cancer Cell Lines Permanently Expressing α2,6-Sialylated Sugar Chains by Transfection with Rat β-Galactoside α2,6 Sialyltransferase cDNABiochemical and Biophysical Research Communications, 1995
- Deficiency of ganglioside biosynthesis in metastatic human melanoma cells: relevance of CMP‐NeuAc: LacCer α2‐3 sialyltransferase (GM3 synthase)FEBS Letters, 1995
- Metastatic potential of transformed rat 3Y1 cell lines is inversely correlated with lysosomal-type sialidase activityFEBS Letters, 1994
- O‐glycan biosynthesis in human colorectal adenoma cells during progression to cancerEuropean Journal of Biochemistry, 1994
- Monoclonal antibody TKH2 to the cancer-associated epitope sialosyl Tn shows cross-reactivity with variants of normal colorectal goblet cell mucinPathology, 1994
- Cloning and Expression of Human Galβ1,3(4)GlcNAc α2,3-SialyltransferaseBiochemical and Biophysical Research Communications, 1993
- The c-Ha-ras oncogene induces increased expression of β-galactoside α-2,6-sialyltransferase in rat fibroblast (FR3T3) cellsGlycobiology, 1992
- α2, 6 sialylation ofN-acetyllactosaminic sequences in human colorectal cancer cell lines. Relationship with non-adherent growthInternational Journal of Cancer, 1991
- Sialic acid dependent cell adhesion to collagen IV correlates with in vivo tumorigenicity of the human colon carcinoma sublines HCT116, HCT116a and HCT116bBiochemical and Biophysical Research Communications, 1990