Mono-N-alkylation of α-aminoacetonitriles. A novel route to unsymmetrical secondary amines
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 667-672
- https://doi.org/10.1039/p19900000667
Abstract
Mannich-type condensation products of an aldehyde with an α-aminoacetonitrile and benzotriazole are treated with sodium borohydride or with a Grignard reagent to give unsymmetrical N,N-dialkylaminoacetonitriles, which, on decyanomethylation, provide unsymmetrical secondary amines.Keywords
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