Abstract
Scientists in academia have struggled to adjust to a policy climate of uncertain funding and loss of freedom from direction and control. How UK life scientists have negotiated this challenge, and with what consequences for their research and the research system, is the empirical entrance point of this paper. We find that policy impacts can be modulated and buffered by strategies and compromises devised and deployed at research performer level. This shifts conceptualisation from terms of responses to one of more or less proactive strategies of scientists and science organisations which add up, intentionally or unintentionally, to shifts in the overall system.

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