PAROTID SECRETION OF IODIDE

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Abstract
Parotid juice from normal human subjects was collected by means of suction cups over the parotid papillae. The iodide content of the secretion was determined at various flow rates with and without the oral administration of potassium iodide, ammonium thiocyanate, and methimazole (Tapazole, Lilly), as these drugs are known to influence iodide metabolism in the thyroid gland. An inverse curvilinear relationship was found between the concentration of iodide and the rate of parotid secretion. Potassium iodide by mouth increased the concentration of parotid juice iodide in the same proportion as the increase in blood level of iodide. The amount of iodide secreted by the parotid glands was depressed by the administration of thiocyanate but was not influenced by the administration of methimazole.

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