Differential selectivity of endothelium‐derived relaxing factor and nitric oxide in smooth muscle
- 1 November 1987
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 92 (3) , 483-485
- https://doi.org/10.1111/j.1476-5381.1987.tb11347.x
Abstract
The selectivity of endothelium‐derived relaxing factor (EDRF) and nitric oxide (NO) on smooth muscle relaxation was examined and compared. EDRF released from bovine pulmonary arterial endothelium (BPAE) in culture and NO were superfused over vascular, tracheal, gastrointestinal and uterine smooth muscle. EDRF relaxed vascular smooth muscle but not tracheal, gastrointestinal or uterine smooth muscle. NO relaxed vascular and gastrointestinal smooth muscle but not tracheal or uterine smooth muscle. There was a differential selectivity between the relaxant effect of EDRF and NO on smooth muscleThis publication has 6 references indexed in Scilit:
- Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorNature, 1987
- Mechanism of action of some inhibitors of endothelium-derived relaxing factor.Proceedings of the National Academy of Sciences, 1986
- Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factorAmerican Journal of Physiology-Heart and Circulatory Physiology, 1986
- Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factorNature, 1986
- Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMPAmerican Journal of Physiology-Cell Physiology, 1986
- The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineNature, 1980