Evidence for a noradrenergic innervation to α1A‐adrenoceptors in rat kidney

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Abstract
Experiments were undertaken to characterize the α1‐adrenoceptor subtype mediating vasoconstrictor responses to periarterial noradrenergic nerve stimulation (PNS) in the isolated perfused kidney of the rat. Vasoconstrictor responses to nerve stimulation were inhibited by prazosin (10 nm), 5‐methyl‐urapidil (30 nm), and nitrendipine (1 μm) but were resistant to inhibition by chloroethylclonidine (100 μm). 5‐Methyl‐urapidil (30 nm), chloroethylclonidine (100 μm) and nitrendipine (1 μm) did not inhibit the neuronal release of tritium from nerves loaded with [3H]‐noradrenaline. The results suggest that renovascular α1A‐adrenoceptors receive a noradrenergic innervation and that the innervated receptors are coupled to dihydropyridine‐sensitive calcium channels.

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