Verification Bias and the Prostate-Specific Antigen Test — Is There a Case for a Lower Threshold for Biopsy?
- 24 July 2003
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 349 (4) , 393-395
- https://doi.org/10.1056/nejme030073
Abstract
Verification bias can influence the interpretation of the most important screening test for prostate cancer, measurement of prostate-specific antigen (PSA). Such bias arises when the presence or absence of prostate cancer has not been verified by prostate biopsy in all subjects in the screened population. In this issue of the Journal, Punglia et al. report on how verification bias alters the sensitivity and specificity of the PSA test, and how this bias can influence the clinical decision about whether to perform a biopsy of the prostate.1 The problem has been recognized previously,2,3 but Punglia et al. address it with . . .Keywords
This publication has 9 references indexed in Scilit:
- Effect of Verification Bias on Screening for Prostate Cancer by Measurement of Prostate-Specific AntigenNew England Journal of Medicine, 2003
- News and AnnouncementsPublished by Wolters Kluwer Health ,2003
- Large‐scale randomized prostate cancer screening trials: Program performances in the European randomized screening for prostate cancer trial and the prostate, lung, colorectal and ovary cancer trialInternational Journal of Cancer, 2001
- Low levels of prostate-specific antigen predict long-term risk of prostate cancer: results from the Baltimore Longitudinal Study of AgingUrology, 2001
- Receiver-operating characteristic as a tool for evaluating the diagnostic performance of prostate-specific antigen and its molecular forms?What has to be considered?The Prostate, 2001
- Predictors for biopsy outcome in the European Randomized Study of Screening for Prostate Cancer (Rotterdam Region)The Prostate, 1999
- Prostate cancer detection in men with serum PSA concentrations of 2.6 to 4.0 ng/mL and benign prostate examination. Enhancement of specificity with free PSA measurementsJAMA, 1997
- Detection of organ-confined prostate cancer is increased through prostate-specific antigen-based screeningPublished by American Medical Association (AMA) ,1993
- Latent carcinoma of the prostateThe Journal of Pathology and Bacteriology, 1954