HYPERSENSITIVITY REACTIONS INDUCED BY ETOPOSIDE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 68  (7-8) , 959-961
Abstract
Eight patients with hypersensitivity to [the antineoplastic drug] etoposide are reported. The clinical characteristics and outcome of the patients are detailed. In 4 patients, treatment was given to ameliorate the symptoms. Two of these patients were successfully retreated with etoposide after premedication with diphenhydramine and hydrocortisone. Hypersensitivity is now recognized as a form of acute toxicity occasionally occurring with this agent. The mechanism is unknown but several possibilities are discussed.

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