STUDIES ON THE EFFECT OF VITAMIN B6 DEPRIVATION ON CARBOHYDRATE METABOLISM IN THE RAT

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Abstract
In vivo and in vitro studies of carbohydrate metabolism were made in the vitamin-B6-deprived rat and its pair-fed control. Within 5 days of vitamin B6 restriction, the fasting levels of blood sugar and liver glycogen were considerably lower. These abnormalities were more marked after 21 days of deprivation and accompanied by significantly lower fasting blood levels of pyruvic and lactic acid. The activity of lactic acid dehydrogenase was measured in vitro and found to be significantly depressed in the vitamin-B6-deprived rat. The abnormal metabolism of carbohydrate which occurs in rats deprived of vitamin B6 is evident early in the deprivation period.