Inhibition ofPlasmodium falciparumGrowth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides
- 1 August 2006
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (8) , 2850-2852
- https://doi.org/10.1128/aac.00313-06
Abstract
A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity againstPlasmodium falciparum(50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.Keywords
This publication has 27 references indexed in Scilit:
- Synthesis, Biological Activity, and Preliminary Pharmacokinetic Evaluation of Analogues of a Phosphosulfomannan Angiogenesis Inhibitor (PI-88)Journal of Medicinal Chemistry, 2005
- Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36Zeitschrift Fur Parasitenkunde-Parasitology Research, 2005
- Inhibition of Chondroitin-4-Sulfate-Specific Adhesion of Plasmodium falciparum -Infected Erythrocytes by Sulfated PolysaccharidesInfection and Immunity, 2005
- Curdlan sulphate in human severe/cerebral Plasmodium falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 2005
- Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agentsInternational Journal for Parasitology, 2000
- Plasmodium falciparum:Molecular Background to Strain-Specific Rosette Disruption by Glycosaminoglycans and Sulfated GlycoconjugatesExperimental Parasitology, 1999
- Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human PlacentaScience, 1996
- Plasmodium falciparum: A Family of Sulfated Glycoconjugates Disrupts Erythrocyte RosettesExperimental Parasitology, 1994
- Plasmodium falciparum erythrocyte rosetting is mediated by promiscuous lectin-like interactions.The Journal of Experimental Medicine, 1992
- Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution techniqueAntimicrobial Agents and Chemotherapy, 1979