New, Abridged Pathway to Masamune's “Southern Hemisphere” Intermediate for the Total Synthesis of Bryostatin 7
- 23 January 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (4) , 503-505
- https://doi.org/10.1021/ol027393m
Abstract
The “Southern Hemisphere” intermediate 2, used by Masamune and co-workers for their asymmetric total synthesis of bryostatin 7 (1), has been synthesized from (E)-1,4-hexadiene (11) by a 24-step pathway that has a longest linear sequence of only 20 steps. This is the shortest synthesis of 2 so far recorded, and moreover, it is fully stereocontrolled.Keywords
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