Increased risk of lymphoproliferative disorders in relatives of patients withB‐cell chronic lymphocytic leukemia: relevance of the degree of familial linkage
- 1 August 2000
- journal article
- research article
- Published by Wiley in European Journal of Haematology
- Vol. 65 (2) , 114-117
- https://doi.org/10.1034/j.1600-0609.2000.90183.x
Abstract
We assessed the familial aggregation of chronic lymphoproliferative diseases (CLD) in 3962 relatives of 169 patients with B‐cell chronic lymphocytic leukemia (B‐CLL). Data collection included a self‐administered questionnaire. The “relative risk” considered the connection between a higher incidence of CLD and the degree of familial linkage with the probands. The model of logistic regression was statistically significant (p<0.001), with the probability of CLD increasing in proportion to the relationship coefficient between parents, siblings and children [(relationship coefficient 0.5; probability of CLD 1.85 (C.I. 95%, range 1.1–3%)]. CLD, particularly B‐CLL, were observed in first‐degree relatives of the patients with B‐CLL more often than in other relatives.Keywords
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