The Action of N-2-Fluorenylacetamide in the Syrian Golden Hamster2

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Abstract
N-2-Fluorenylacetamide was fed at a 0.04 percent level in the diet to female and male Syrian golden hamsters for 40 or 26 weeks. A high incidence of benign cholangiomatous lesions and some cholangiocarcinomas were seen. Outside of the liver, only 1 colonic adenocarcinoma, 1 leiomyosarcoma, and 1 generalized lymphoma were observed that were not believed to be related to the experimental diet. No parenchymal liver-cell tumors were observed. No definite differences between the male and female response were noted. The pathological findings are discussed in the light of their histopathogenesis.

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