Primary Secretion of Insulin and Secondary Release of Glucagon from the Isolated Perfused Rat Pancreas Following Stimulation with Pancreozymin

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Abstract
Pancreozymin stimulates glucagon and insulin release independently of the autonomous nervous system in the isolated perfused rat pancreas in vitro. Dynamics of secretion show primary release of insulin and secondary secretion of glucagon. Presence or absence of glucose in the perfusion medium influences this pattern inversely: glucose concentrations of about 100 mg % potentiate insulin release and decrease glucagon secretion, whereas absence of glucose is accompanied by augmentation of glucagon, and depression of insulin secretion.