HAEMODYNAMIC CHANGES IN THE MONCADA MODEL OF ATHEROSCLEROSIS

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Abstract
SUMMARY: 1. The application of a non‐constricting silastic cuff to the rabbit common carotid artery (CCA; n= 5) results in intimal thickening within 7 days.2. Ultrasonography showed kinking of the CCA at the cuff edges, as well as a 13% arterial narrowing (P < 0.02) within the cuffed segment, both at days 1 and 7. Correspondingly, the time averaged diastolic Doppler velocity (TAV) was 68.8 ± 12.8% higher (P < 0.025) in the cuffed region in comparison with that 1 cm proximal (P 1 cm) on day 1, and 54.2 ± 11.5% higher at day 7(P < 0.05). TAV values along control silastic strips were not significantly changed.3. There was a significant increase (P < 0.025) in intimal area within the cuffed region (0.098 ±0.024 mm3) compared with both the proximal control (0.014 ±0.001 mm3) and with that over control silastic strips (0.021 ±0.004 mm3, P < 0.01).4. Medial area within the cuff (0.433 ±0.017 mm3) was decreased (P < 0.005) compared with P 1 cm control (0.602 ±0.069 mm3).5. There was gross peri‐arteritic thickening involving the adventitia along the non‐constricted cuffed segment. Importantly, it was also noted alongside the control silastic strip.6. Kinking of the CCA and associated vasoconstriction cause changes in blood flow velocity along even a non‐constricting cuff, and this may explain the intimal thickening previously noted in this experimental model. The peri‐arteritic changes, on the other hand, appear to be a reaction to the silastic itself.