Cyclic guanidines. XVI. Synthesis and biological activities of tetracyclic imidazo(2,1-b)quinazolinone derivatives.

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Abstract
Tetracyclic imidazo[2,1-b]quinazolinone derivatives (18) with a modified or unmodified alkylene chain were prepared and evaluated for their ability to inhibit platelet aggregation. Most of the compounds were very potent except for some compounds substituted with an amino or a hydroxy group. The structure-activity relationships are discussed.

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